segregation of chromosome的意思|示意

Objective:To investigate the effect of BUB1 expression in embryonic cells on chromosome segregation.

目的：研究BUB1基因表达调控对染色体分离的影响。

Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability.

多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。

Accurate chromosome segregation depends on the precise regulation of mitotic progression, including the timing of mitosis and proper regulation of spindle assembly checkpoint.

准确的染色体分离依赖于有丝分裂过程的精确调控，包括有丝分裂的时间，及纺锤体检查点的正确调控等。

Objective genetic instability is one of the most important factors to underlie neoplasia, and precise segregation of the chromosome is critical for stable inheritance of genetic material.

研究目的遗传的不稳定性是肿瘤生成的最重要的因素之一，而染色体的精确分离是基因物质稳定遗传关键。