dry granulation的意思|示意

Dry granulation is a process used to compress powdered materials into solid granules with or without the aid of a binding agent. This process is commonly used in pharmaceutical and food processing industry for the production of solid tablets and capsules.

The process of dry granulation can be categorized into two types: slugging process and roll compaction process. In the slugging process, the powder is formed into small pellets, called slugs, by compression and then the slugs are milled into the desired granule size. The roll compaction process is usually used when large production is required. In this process, powder material is compressed between rollers to create a dense, continuous sheet, which is then milled into granules. It is common to add lubricants such as waxes to stabilize and lubricate the slugs in the slugging process. Additionally, binding agents such as starches, celluloses, and polyethylene glycols can be added to the powdered material to provide cohesion and eliminate or reduce the amount of dust generated during the process.

The use of dry granulation in pharmaceuticals is beneficial because it offers good flow properties, uniform tablet hardness, good dissolution characteristics, and relatively low manufacturing costs compared to other granulation processes. Furthermore, there is less waste generated since the process does not involve water or other additives.

In conclusion, dry granulation is an important process used in pharmaceuticals and food processing industries. The benefits of this process include uniform tablet hardness, good dissolution characteristics, and low costs. Additionally, dry granulation is advantageous because it reduces waste generation compared to other granulation processes.